Rabbit Anti-AR

【資料簡(jiǎn)介】

 

Rabbit Anti-AR

Catalog Number :HZ579129      Quantity size :   0.1ml （dilute with pH 7.4    0.01 M PBS or antibody diluent ）

Background:  Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and make reproductive physiology. The androgen receptor （AR） is a member of the steroid superfamily of liganddependent transcription factors. ARs bind the two biologically active andro gens, testosterone （T） and dihydrotestosterone （DHT）, with high and nearly identical affinities; however , the rates of association and dissociation of T are about three times more rapid than those of DHT. This difference has resulted in speculation as to whether these differences in binding kinetics could account for the different physiological effects of T and DHT. A striking feature of AR is its rapid degradation in the absence of ligand. It is now well established that androgen binding results in an at least six-fold increase in androgen stability and that ligand-induced stabilization of AR is highly androgen- specific.

pecificity :   

–        Anti-AR is a rabbit polyclonal antibody unconjugated                

–         specific for AR of human, mouse, rat          

–         use for western blotting,elisa,immunoprecipitation and immunohistochemistry

–         Protein G affinity chromatography purification, purity :>95%

–         Isotype:  IgG

–         mol wt:  110kDa

Rabbit Anti-AR

Application :  

–        Western blotting 1:100-500                

–         Immunohistochemistry 1:100-500                 

–         ELISA 1:500-1000                  

–         Optimal working dilutions must be determined by the end user.

Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃

 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Rabbit Anti-AR